The Facebook founder and his wife,
paediatrician Priscilla Chan, said the goal was to “cure, prevent or manage all disease within our children’s lifetime”.
Investment will go towards research into cancer and infectious disease as well as heart and neurological disease, the couple said.
The plans were revealed during an event in San Francisco for their philanthropic group, the Chan Zuckerberg Initiative, on Wednesday.
Dr Chan said they had launched the initiative following the birth of daughter Max last year, with the goal of dramatically improving the
lives of all other children in her generation.